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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestim</journal-id><journal-title-group><journal-title xml:lang="ru">Известия Национальной  академии наук Беларуси. Серия медицинских наук</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of the National Academy of Sciences of Belarus, Medical series</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-6023</issn><issn pub-type="epub">2524-2350</issn><publisher><publisher-name>The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vestim-320</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL AND EXPERIMENTAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>УЛЬТРАСТРУКТУРНАЯ ПЕРЕСТРОЙКА ТКАНЕЙ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ ПРИ ХРОНИЧЕСКОМ ПАНКРЕАТИТЕ</article-title><trans-title-group xml:lang="en"><trans-title>ULTRASTRUCTURAL RESTRUCTURING THE PANCREATIC TISSUE IN CHRONIC PANCREATITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ШУЛЕЙКО</surname><given-names>А. Ч.</given-names></name><name name-style="western" xml:lang="en"><surname>SHULEIKA</surname><given-names>A. Ch.</given-names></name></name-alternatives><email xlink:type="simple">shuleika1961@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ВОРОБЕЙ</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>VARABEI</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>НОВАКОВСКАЯ</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>NOVAKOVSKAYA</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">novakovskaya@tut.by</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>АРЧАКОВА</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>ARCHAKOVA</surname><given-names>L. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Белорусская медицинская академия последипломного образования</institution></aff><aff xml:lang="en"><institution>Belarusian Medical Academy of Postgraduate Education</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт физиологии НАН Беларуси</institution></aff><aff xml:lang="en"><institution>Institute of Physiology of the National Academy of Sciences of Belarus</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>19</day><month>11</month><year>2016</year></pub-date><volume>0</volume><issue>3</issue><fpage>47</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ШУЛЕЙКО А.Ч., ВОРОБЕЙ А.В., НОВАКОВСКАЯ С.А., АРЧАКОВА Л.И., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">ШУЛЕЙКО А.Ч., ВОРОБЕЙ А.В., НОВАКОВСКАЯ С.А., АРЧАКОВА Л.И.</copyright-holder><copyright-holder xml:lang="en">SHULEIKA A.C., VARABEI A.V., NOVAKOVSKAYA S.A., ARCHAKOVA L.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestimed.belnauka.by/jour/article/view/320">https://vestimed.belnauka.by/jour/article/view/320</self-uri><abstract><p>Представлены результаты изучения препаратов поджелудочной железы (ПЖ) 20 оперированных пациентов с хроническим панкреатитом (ХП) с помощью электронной микроскопии. Установлено, что при ХП в ПЖ на клеточном уровне происходит непрерывный процесс некробиоза с вовлечением всех структур железы: протоков, ацинарной ткани, нервов. Выявлено большое количество звездчатых клеток, определяющих развитие фиброза ПЖ. На основании результатов исследования установлено, что причиной прогрессирования перидуктального фиброза может быть стимуляция звездчатых клеток вторичной ишемией ткани ПЖ.</p></abstract><trans-abstract xml:lang="en"><p>Представлены результаты изучения препаратов поджелудочной железы (ПЖ) 20 оперированных пациентов с хроническим панкреатитом (ХП) с помощью электронной микроскопии. Установлено, что при ХП в ПЖ на клеточном уровне происходит непрерывный процесс некробиоза с вовлечением всех структур железы: протоков, ацинарной ткани, нервов. Выявлено большое количество звездчатых клеток, определяющих развитие фиброза ПЖ. На основании результатов исследования установлено, что причиной прогрессирования перидуктального фиброза может быть стимуляция звездчатых клеток вторичной ишемией ткани ПЖ.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический панкреатит</kwd><kwd>морфологическое исследование</kwd><kwd>электронная микроскопия</kwd><kwd>звездча- тые клетки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>хронический панкреатит</kwd><kwd>морфологическое исследование</kwd><kwd>электронная микроскопия</kwd><kwd>звездча- тые клетки</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Worning, H. Incidence and prevalence of chronic pancreatitis / H. Worning // Chronic Pancreatitis / eds: H. G. Beger, M. Büchler, H. Ditschuneit, P. Malfertheiner. – Berlin: Heidelberg Springer, 1990. – P. 8–14.</mixed-citation><mixed-citation xml:lang="en">Worning, H. 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