vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-315Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEБЕЛКИ СИСТЕМЫ КОМПЛЕМЕНТА С3, С4 И NGAL – ФАКТОРЫ ТЯЖЕСТИ ПОЧЕЧНОГО ПОВРЕЖДЕНИЯ У ДЕТЕЙ С ГЕМОЛИТИКО-УРЕМИЧЕСКИМ СИНДРОМОМCOMPLEMENT PROTEINS C3, C4 AND NGAL ARE THE FACTORS OF THE SEVERITY OF KIDNEY DAMAGE IN CHILDREN WITH THE HEMOLYTIC-UREMIC SYNDROMEБАЙКОС. В.BAIKOS. V.baiko@yandex.ruСУКАЛОА. В.SUKALOA. V.kafedra.pediatria1@yandex.byБелорусский государственный медицинский университетBelarusian State Medical UniversityБелорусский государственный медицинский университет; Национальная академия наук Беларуси,Belarusian State Medical University; Belarusian National Academy of Sciences201619112016031319Copyright © БАЙКО С.В., СУКАЛО А.В., 20162016БАЙКО С.В., СУКАЛО А.В.BAIKO S.V., SUKALO A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/315

Цель работы – определить изменение уровней нейтрофильного желатиназо-ассоциированного липокалина (NGAL), белков системы комплемента С3, С4 в крови детей с гемолитико-уремическим синдромом (ГУС) и найти взаимосвязи между ними и факторами, определяющими тяжесть почечного повреждения. Проспективное исследование включало 159 детей: 35 – в острой фазе ГУС, 124 – перенесших ГУС не ранее чем через 6 мес. после выписки из стационара и 28 – практически здоровых детей. Обнаружено повышение NGAL у всех детей с ГУС, наиболее выраженное у нуждавшихся в заместительной почечной терапии. Выявлена активация альтернативного пути системы комплемента при ГУС Д «+», обусловленная снижением фракции С3 при нормальном уровне С4. Установлено, что между повышением NGAL и снижением комплемента С3 имеется тесная корреляционная связь с параметрами, отражающими тяжесть почечного повреждения.

The purpose of this study was to determine changes of levels of blood neutrophil gelatinase- associated lipocalin (NGAL), complement proteins C3 and C4 in children with hemolytic-uremic syndrome (HUS) and to find the relationship between them and factors determining the severity of renal damage. A prospective study included 159 children: 35 in the acute phase of HUS, 124 – after HUS, at least 6 months after discharge from the hospital and 28 healthy children. NGAL was elevated in all children with HUS more pronounced in those who required renal replacement therapy. Activation of the alternative pathway of the complement system in HUS D "+" due to reduced C3 and normal C4 levels was found. The degree of increasing NGAL and decreasing complement C3 has a close correlation with parameters reflecting the severity of renal damage.

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The authors declare that there are no conflicts of interest present.