vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-297Research ArticleОБЗОРЫREVIEWSСтруктурно-функциональные особенности Nox2-НАД(Ф)Н-оксидазыStructural and functional features of Nox2-NAD(P)H-oxidaseБизунокН. А.BizunokN. A.okna@bsmu.byБелорусский государственный медицинский университетBelarusian State Medical University20160101201601117128Copyright © Бизунок Н.А., 20162016Бизунок Н.А.Bizunok N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/297

В контексте развития направлений разработки способов и средств управления редокс-зависимыми процессами в организме человека в настоящей работе отражены как история развития научных представлений об одном из важнейших биологических генераторов активных форм кислорода - №ж2-НАДФН-оксидазе (К.Ф.1.6.3.1, Nox2), так и современный взгляд на особенности локализации и молекулярного строения этого ферментного комплекса, а также на спектр и биологическое значение активных форм кислорода, генерируемых при его участии.

In the context of the development of ways and means to control the redox-dependent processes in the human body, the present article deals with the history of the scientific ideas of Nox2-NADPH oxidase (Е.С.1.6.3.1, Nox2) - one of the most important biological generator of reactive oxygen species (ROS), the current understanding of the peculiarities of localization and molecular structure of the enzyme complex, the spectrum, and the biological significance of reactive oxygen species generated by its participation.

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The authors declare that there are no conflicts of interest present.