vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-220Research ArticleОБЗОРЫREVIEWSСеротонин и синдром обструктивного апноэ во снеSerotonin and obsructive sleep apneaТропниковаГ. К.TropnikovaG. K.biblio@fizio.bas-net.byИнститут физиологии НАНБеларусиInstitute of Physiology of the National Academy of Sciences of Belarus20150606201604114128Copyright © Тропникова Г.К., 20162016Тропникова Г.К.Tropnikova G.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/220
-рецепторов и гена транспортера 5-НТ к повышенной предрасположенности к развитию СОАС.
-receptors and 5-HT transporter gene to an increased susceptibility to OSA.
ReferencesWhite, D. P. Obstructive sleep apnea / D. P. White, M. K. Younes // Comp. Physiol. - 2012. - Vol. 2, N 4. - P. 25412594.White, D. P. Obstructive sleep apnea / D. P. White, M. K. Younes // Comp. Physiol. - 2012. - Vol. 2, N 4. - P. 25412594.Noradrenergic modulation of hypoglossal motoneuron excitability: developmental and putative state-dependent mechanisms / G. D. Funk [et al.] // Arch. Ital. Biol. - 2011. - Vol. 149, N 4. - P. 426-453.Noradrenergic modulation of hypoglossal motoneuron excitability: developmental and putative state-dependent mechanisms / G. D. Funk [et al.] // Arch. Ital. Biol. - 2011. - Vol. 149, N 4. - P. 426-453.Tadjalli, A. Identification of novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback / A. Tadjalli, J. Duffin, J. Peever // J. Neurosci. - 2010. - Vol. 30. - P. 16886-16895.Tadjalli, A. Identification of novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback / A. Tadjalli, J. Duffin, J. Peever // J. Neurosci. - 2010. - Vol. 30. - P. 16886-16895.Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-wake state determination / M. C. Bellingham [et al.] // Clin. Exp. Pharmacol. Physiol. - 2000. - Vol. 27, N 1-2. - P. 132-137.Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-wake state determination / M. C. Bellingham [et al.] // Clin. Exp. Pharmacol. Physiol. - 2000. - Vol. 27, N 1-2. - P. 132-137.Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea / A. S. Jordan [et al.] // J. Appl. Physiol. - 2005. - Vol. 99, N 5. - P. 2020-2027.Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea / A. S. Jordan [et al.] // J. Appl. Physiol. - 2005. - Vol. 99, N 5. - P. 2020-2027.Plasticity in respiratory motor control: intermittent hypoxia and hypercapnia activate opposing serotoninergic and noradrenergic modulatory systems / R. Kinkead [et al.] // Comp. Biochem Physiol. A Mol. Inter. Physiol. - 2001. - Vol. 130. - P. 207-218.Plasticity in respiratory motor control: intermittent hypoxia and hypercapnia activate opposing serotoninergic and noradrenergic modulatory systems / R. Kinkead [et al.] // Comp. Biochem Physiol. A Mol. Inter. Physiol. - 2001. - Vol. 130. - P. 207-218.Weissheimer, K. V. Inhibitory modulation of chemoreflex bradycardia by stimulation on the nucleus raphe obscurus is mediated by 5-НТ3 receptors in the NTS of awake rats / K. V. Weissheimer, B. N. Machade // Auton. Neurosci. - 2007. -Vol. 132, N 1-2. - P. 27-36.Weissheimer, K. V. Inhibitory modulation of chemoreflex bradycardia by stimulation on the nucleus raphe obscurus is mediated by 5-НТ3 receptors in the NTS of awake rats / K. V. Weissheimer, B. N. Machade // Auton. Neurosci. - 2007. -Vol. 132, N 1-2. - P. 27-36.Serotonin depletion increases respiratory variability in freely moving rats: implication for panic disorder / K. Annerbrink [et al.] // Int. J. Neuropsychopharmacol. - 2003. - Vol. 6, N 1. - P. 51-56.Serotonin depletion increases respiratory variability in freely moving rats: implication for panic disorder / K. Annerbrink [et al.] // Int. J. Neuropsychopharmacol. - 2003. - Vol. 6, N 1. - P. 51-56.Александрин, В. Д. Влияние серотонина на дыхание, мозговой кровоток и артериальное давление у крыс / B. Д. Александрин, Н. Н. Тарасова, И. А. Тараканов // Бюл. эксперим. биол. и мед. - 2005. - № 1. - С. 72-76.Александрин, В. Д. Влияние серотонина на дыхание, мозговой кровоток и артериальное давление у крыс / B. Д. Александрин, Н. Н. Тарасова, И. А. Тараканов // Бюл. эксперим. биол. и мед. - 2005. - № 1. - С. 72-76.Injection of glutamate into the insular cortex produces sleep apnea and serotonin reduction in rats / L. Cui [et al.] // Sleep Breath. - 2012. - Vol. 16, N 3. - P. 845-853.Injection of glutamate into the insular cortex produces sleep apnea and serotonin reduction in rats / L. Cui [et al.] // Sleep Breath. - 2012. - Vol. 16, N 3. - P. 845-853.Azmitia, E. Ch. Serotonin neurons, neuroplasticity, and homeostasis of neural tissue / E. Ch. Azmitia // Neuropsicho-pharmacology. - 1999. - Vol. 21, N 2. - Р. 33-45.Azmitia, E. Ch. Serotonin neurons, neuroplasticity, and homeostasis of neural tissue / E. Ch. Azmitia // Neuropsicho-pharmacology. - 1999. - Vol. 21, N 2. - Р. 33-45.Martinowich, K. Interaction between BDNF and serotonin: role in mood disorders / K. Martinowich, B. Lu // Neuropsiopharmacology. - 2008. - Vol. 33, N 1. - P. 73-83.Martinowich, K. Interaction between BDNF and serotonin: role in mood disorders / K. Martinowich, B. Lu // Neuropsiopharmacology. - 2008. - Vol. 33, N 1. - P. 73-83.Effects of electrical stimulation on the medullary raphe nuclei on respiratory movements in tats / Y. Cao [et al.] // J. Comp. Physiol. - 2006. - Vol. 102, N 5. - P. 507.Effects of electrical stimulation on the medullary raphe nuclei on respiratory movements in tats / Y. Cao [et al.] // J. Comp. Physiol. - 2006. - Vol. 102, N 5. - P. 507.The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis / H. C. Kinney [et al.] // J. Chem. Neuroanat. - 2011. - Vol. 41, N 4. - P. 182-199.The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis / H. C. Kinney [et al.] // J. Chem. Neuroanat. - 2011. - Vol. 41, N 4. - P. 182-199.Selective lesion of retrotrapezoid Phhox2b-expressing neurons raises the the apnoetic threshold in rats / A. C. Taka-kakeora [et al.] // J. Physiol. - 2008. - Vol. 586. - P. 2975-2991.Selective lesion of retrotrapezoid Phhox2b-expressing neurons raises the the apnoetic threshold in rats / A. C. Taka-kakeora [et al.] // J. Physiol. - 2008. - Vol. 586. - P. 2975-2991.Raphe pallidus modulates Botzinger complex-induced inhibition of the phrenic nerve activity in rats / S. Y. Yu [et al.] // Eur. J. Neurosci. - 2011. - Vol. 34, N 7. - P. 1113-1120.Raphe pallidus modulates Botzinger complex-induced inhibition of the phrenic nerve activity in rats / S. Y. Yu [et al.] // Eur. J. Neurosci. - 2011. - Vol. 34, N 7. - P. 1113-1120.Lalley, P. M. Responses of phrenic motoneurones of the cat to stimulation of medullary raphe nuclei / P. M. Lally // J. Physiol. - 1986. - Vol. 380. - P. 349-371.Lalley, P. M. Responses of phrenic motoneurones of the cat to stimulation of medullary raphe nuclei / P. M. Lally // J. Physiol. - 1986. - Vol. 380. - P. 349-371.Kumaido, K. Studies on the respiratory control mechanism of medullary raphe nuclei and their serotonergic system / K. Kumaido // No To Shinkei. - 1988. - Vol. 40, N 10. - P. 929-938.Kumaido, K. Studies on the respiratory control mechanism of medullary raphe nuclei and their serotonergic system / K. Kumaido // No To Shinkei. - 1988. - Vol. 40, N 10. - P. 929-938.Serotonin induced in vitro long-term facilitation exhibits differentional pattern sensitivity in cervical and thoracic motor output / M. R. Lovett-Barr [et al.] // Neuroscience. - 2006. - Vol. 142, N 3. - P. 885-892.Serotonin induced in vitro long-term facilitation exhibits differentional pattern sensitivity in cervical and thoracic motor output / M. R. Lovett-Barr [et al.] // Neuroscience. - 2006. - Vol. 142, N 3. - P. 885-892.Bouryl, V. A. The modulation by 5-HT of glutamatergic inputs from the raphe pallidus in rats hypoglossal motoneurones in vitro / V. A. Bouryl, D. I. Lewis // J. Physiol. - 2003. - Vol. 553. - Pt 3. - P. 1019-1031.Bouryl, V. A. The modulation by 5-HT of glutamatergic inputs from the raphe pallidus in rats hypoglossal motoneurones in vitro / V. A. Bouryl, D. I. Lewis // J. Physiol. - 2003. - Vol. 553. - Pt 3. - P. 1019-1031.Loewy, A. D. Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat / A. D. Loewy, S. McKellar // Brain Res. - 1981. - Vol. 211, N 1. - P. 146-152.Loewy, A. D. Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat / A. D. Loewy, S. McKellar // Brain Res. - 1981. - Vol. 211, N 1. - P. 146-152.Buchanan, G. F. Central 5-HT neurons are required for arousal to CO2 / G. F. Buchanan, G. B. Richerson // Proceed. of the Nat. Acad. Sci. - 2010. - Vol. 107. - P. 16354-16359.Buchanan, G. F. Central 5-HT neurons are required for arousal to CO2 / G. F. Buchanan, G. B. Richerson // Proceed. of the Nat. Acad. Sci. - 2010. - Vol. 107. - P. 16354-16359.Medullary serotonin neurons and central CO2 chemoreception / A. E. Corcoran [et al.] // Resp. Physiol. Neurobiol. -2009. - Vol. 168, N 1-2. - P. 49-58.Medullary serotonin neurons and central CO2 chemoreception / A. E. Corcoran [et al.] // Resp. Physiol. Neurobiol. -2009. - Vol. 168, N 1-2. - P. 49-58.Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons / M. R. Hodges [et al.] // J. Neurosci. - 2008. - Vol. 28. - P. 2495-2505.Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons / M. R. Hodges [et al.] // J. Neurosci. - 2008. - Vol. 28. - P. 2495-2505.Impaired respiratory and body temperature control upon acute serotoninergic neuron inhibition / R. S. Ray [et al.] // Science. - 2011. - Vol. 333. - P. 637-642.Impaired respiratory and body temperature control upon acute serotoninergic neuron inhibition / R. S. Ray [et al.] // Science. - 2011. - Vol. 333. - P. 637-642.Edwards, B. A. Obstructive sleep apnea in older adults is a distinctly different physiological phenotype / B. A. Edwards, A. Wellman, S. A. Sands // Sleep. - 2014. - Vol. 37, N 7. - P. 1227-1236.Edwards, B. A. Obstructive sleep apnea in older adults is a distinctly different physiological phenotype / B. A. Edwards, A. Wellman, S. A. Sands // Sleep. - 2014. - Vol. 37, N 7. - P. 1227-1236.Song, G. Projections of 5-HT-ergic fibers to the spinal phrenic nucleus and medullary phrenic premotor neurons in the cat / G. Song, Q. Li, F. Z. Shao // Sheng Li Xue Bao. - 2001. - Vol. 53, N 5. - P. 391-395.Song, G. Projections of 5-HT-ergic fibers to the spinal phrenic nucleus and medullary phrenic premotor neurons in the cat / G. Song, Q. Li, F. Z. Shao // Sheng Li Xue Bao. - 2001. - Vol. 53, N 5. - P. 391-395.Li, P. Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during elec-troacupuncture / P. Li, S. C. Tjen-A-Looi , J. C. Longhurst // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2010. - Vol. 299, N 5. - P. 1369-1376.Li, P. Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during elec-troacupuncture / P. Li, S. C. Tjen-A-Looi , J. C. Longhurst // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2010. - Vol. 299, N 5. - P. 1369-1376.Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture / A. Moazzami [et al.] // J. Appl. Physiol. - 2010. - Vol. 108, N 5. - P. 1336-1346.Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture / A. Moazzami [et al.] // J. Appl. Physiol. - 2010. - Vol. 108, N 5. - P. 1336-1346.Control of breathing by raphe obscurus serotonergic neurons in mice / S. D. Depuy [et al.] // J. Neurosci. - 2011. -Vol. 31, N 6. - P. 1981-1990.Control of breathing by raphe obscurus serotonergic neurons in mice / S. D. Depuy [et al.] // J. Neurosci. - 2011. -Vol. 31, N 6. - P. 1981-1990.Ihibition of serotoninergic medullary raphe obscurus neurons suppress genioglossus and diaphragm activities in an-asthetized but not conscious rats / S. Sood [et al.] // J. Appl. Physiol. (1985). - 2006. - Vol. 100, N 6. - P. 1807-1821.Ihibition of serotoninergic medullary raphe obscurus neurons suppress genioglossus and diaphragm activities in an-asthetized but not conscious rats / S. Sood [et al.] // J. Appl. Physiol. (1985). - 2006. - Vol. 100, N 6. - P. 1807-1821.Involvement of medullary GABAergic and serotonergic raphe neurons in respiratory control:electrophysiological and immunohistochemical studies in rats / Y. Cao [et al.] // Neurosci. Res. - 2006. - Vol. 56, N 3. - P. 322-331.Involvement of medullary GABAergic and serotonergic raphe neurons in respiratory control:electrophysiological and immunohistochemical studies in rats / Y. Cao [et al.] // Neurosci. Res. - 2006. - Vol. 56, N 3. - P. 322-331.Futuro-Neto, H. A. Desinchronized sleep-like pattern of sympathttic activity elicited by electrical stimulation of sites in the brainstem / H. A. Futuro-Neto, J. H. Coote // Brain Res. - 1982. - Vol. 252, N 2. - P. 269-276.Futuro-Neto, H. A. Desinchronized sleep-like pattern of sympathttic activity elicited by electrical stimulation of sites in the brainstem / H. A. Futuro-Neto, J. H. Coote // Brain Res. - 1982. - Vol. 252, N 2. - P. 269-276.Serotonergic neurons in the nucleus raphe obscurus contribute to interaction between central and peripheral ventilatory responses to hypercapnia / G. S. da Silva [et al.] // Pflugers Arch. - 2011. - Vol. 462, N 3. - P. 407-418.Serotonergic neurons in the nucleus raphe obscurus contribute to interaction between central and peripheral ventilatory responses to hypercapnia / G. S. da Silva [et al.] // Pflugers Arch. - 2011. - Vol. 462, N 3. - P. 407-418.Carley, D. W. Role of peripheral serotonin in the regulation of control sleep apneas in rats. / D. W. Caley, M. Ra-dulovacki // Chest. - 1999. - Vol. 115. - P. 1397-1401.Carley, D. W. Role of peripheral serotonin in the regulation of control sleep apneas in rats. / D. W. Caley, M. Ra-dulovacki // Chest. - 1999. - Vol. 115. - P. 1397-1401.Pharmacological characterirization 5-HT-induced apnea in the rat / M. Yoshioka [et al.] // J. Pharmacol. Exp. Ther. -1992. - Vol. 260. - P. 917-924.Pharmacological characterirization 5-HT-induced apnea in the rat / M. Yoshioka [et al.] // J. Pharmacol. Exp. Ther. -1992. - Vol. 260. - P. 917-924.Radulovacki, M. Serotonin 5-HT3-receptor antagonist Gr3032 F suppresses sleep apneas in rats / M. Radulovacki, S. M. Trbovic, D. W. Carley // Sleep. - 1998. - Vol. 21. - P. 131-136.Radulovacki, M. Serotonin 5-HT3-receptor antagonist Gr3032 F suppresses sleep apneas in rats / M. Radulovacki, S. M. Trbovic, D. W. Carley // Sleep. - 1998. - Vol. 21. - P. 131-136.Fenik, P. Hypoglossal nerve response to 5-HT3-drugs injected into the XII nucleus and vena cava in the rat / P. Fenik, H. Ogawa, S. G. Veasey // Sleep. - 2001. - Vol. 24. - P. 871-878.Fenik, P. Hypoglossal nerve response to 5-HT3-drugs injected into the XII nucleus and vena cava in the rat / P. Fenik, H. Ogawa, S. G. Veasey // Sleep. - 2001. - Vol. 24. - P. 871-878.The effects of ondansetron on sleep-disordered breathing in the English bulldog / S. C. Veasey [et al.] // Sleep. - 2001. -Vol. 24. - P. 155-160.The effects of ondansetron on sleep-disordered breathing in the English bulldog / S. C. Veasey [et al.] // Sleep. - 2001. -Vol. 24. - P. 155-160.Mason, M. Drug theraphy for obstructive sleep apnea in adults / M. Mason, E. L. Welsh, U. Smith // Cochrane Database syst. Rev. - 2013. - Vol. 5. - P. CD 003002.Mason, M. Drug theraphy for obstructive sleep apnea in adults / M. Mason, E. L. Welsh, U. Smith // Cochrane Database syst. Rev. - 2013. - Vol. 5. - P. CD 003002.Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome / B. Prasad [et al.] // Sleep. - 2010. - Vol. 33. - P. 982-987.Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome / B. Prasad [et al.] // Sleep. - 2010. - Vol. 33. - P. 982-987.Peppard, P. E. Increased prelevance of sleep-disordered breathing in adults / P. E. Peppard, T. Young, J. H. Barnet // Am. J. Epidemiol. - 2013. - Vol. 177. - P. 1006-1014.Peppard, P. E. Increased prelevance of sleep-disordered breathing in adults / P. E. Peppard, T. Young, J. H. Barnet // Am. J. Epidemiol. - 2013. - Vol. 177. - P. 1006-1014.Obstructive sleep apnea among hospitalized patients in Spain; analysis of hospital discharge data 2008-2012 / J. de Miguel-Diez [et al.] // Sleep Breath. - 2015. - N 1.Obstructive sleep apnea among hospitalized patients in Spain; analysis of hospital discharge data 2008-2012 / J. de Miguel-Diez [et al.] // Sleep Breath. - 2015. - N 1.Edwards, E. Glutamate stimulation of raphe pallidus attenuates the cardiopulmonary reflex in anasthetized rats / E. Edwards, J. F. Paton // Auto. Neurosci. - 2000. - Vol. 82, N 3. - P. 87-96.Edwards, E. Glutamate stimulation of raphe pallidus attenuates the cardiopulmonary reflex in anasthetized rats / E. Edwards, J. F. Paton // Auto. Neurosci. - 2000. - Vol. 82, N 3. - P. 87-96.Mоhamed, S. Respiratory long-term facilitation: too much or too little of good thing? / S. Mоhamed, G. S. Mitchell // Adv. Exp. Med. Biol. - 2008а. - Vol. 605. - P. 224-227.Mоhamed, S. Respiratory long-term facilitation: too much or too little of good thing? / S. Mоhamed, G. S. Mitchell // Adv. Exp. Med. Biol. - 2008а. - Vol. 605. - P. 224-227.Mоhamad, S. Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats / S. Mоhamad, G. S. Mitchell // J. Physiol. - 2008b. - Vol. 586, N 8. - P. 2171-2181.Mоhamad, S. Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats / S. Mоhamad, G. S. Mitchell // J. Physiol. - 2008b. - Vol. 586, N 8. - P. 2171-2181.Acute intermittent hypoxia induces phrenic long-term facilitation wich is modulated by 5-HT1receptor in the caudal raphe region of the rat / D. Parlinac [et al.] // J. Sleep Res. - 2012. - Vol. 21, N 2. - P. 195-203.Acute intermittent hypoxia induces phrenic long-term facilitation wich is modulated by 5-HT1receptor in the caudal raphe region of the rat / D. Parlinac [et al.] // J. Sleep Res. - 2012. - Vol. 21, N 2. - P. 195-203.Baker-Herman, T. L. Phrenic long-term facilitation requires spinal serotonin receptor facilitation and protein synthesis / T. L. Baker-Herman, G. S. Mitchell // J. Neurosci. - 2002. - Vol. 22. - P. 6239-6246.Baker-Herman, T. L. Phrenic long-term facilitation requires spinal serotonin receptor facilitation and protein synthesis / T. L. Baker-Herman, G. S. Mitchell // J. Neurosci. - 2002. - Vol. 22. - P. 6239-6246.Baker-Herman, T. L. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia / T. L. Baker-Herman, D. D. Fuller, R. M. Bavis // Nat. Neurosci. - 2004. - V>l. 7. - P. 48-55.Baker-Herman, T. L. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia / T. L. Baker-Herman, D. D. Fuller, R. M. Bavis // Nat. Neurosci. - 2004. - V>l. 7. - P. 48-55.Phrenic long-term facilitation requires 5-HT-receptors activation during but not following episodic hypoxia / D. D. Fuller [et al.] // J. Appl. Physiol. - 2001. - Vol. 90. - P. 2001-2006.Phrenic long-term facilitation requires 5-HT-receptors activation during but not following episodic hypoxia / D. D. Fuller [et al.] // J. Appl. Physiol. - 2001. - Vol. 90. - P. 2001-2006.Mc Grimmon, D. R. Involvement of excitatory amino acids in neurotransmission of inspiratore drive to spinal respiratory motoneurons / D. R. Mc Grimmon, J. C. Smith, J. L. Feldman // J. Neurosci. - 1989. - Vol. 9. - P. 1910-1921.Mc Grimmon, D. R. Involvement of excitatory amino acids in neurotransmission of inspiratore drive to spinal respiratory motoneurons / D. R. Mc Grimmon, J. C. Smith, J. L. Feldman // J. Neurosci. - 1989. - Vol. 9. - P. 1910-1921.Respiratory activation of the genioglossus muscle involves both non-NMDA and NMDA glutamate receptors at the hypoglossal motor nucleus in vivo / H. W. Steenland [et al.] // Neuroscience. - 2006. - Vol. 138. - P. 1407-1424.Respiratory activation of the genioglossus muscle involves both non-NMDA and NMDA glutamate receptors at the hypoglossal motor nucleus in vivo / H. W. Steenland [et al.] // Neuroscience. - 2006. - Vol. 138. - P. 1407-1424.Mitchell, G. S. Neuroplasticity in respiratory motor control / G. S. Mitchell, S. M. Johnson // J. Appl. Physiol. - 2003. -Vol. 94. - P. 358-374.Mitchell, G. S. Neuroplasticity in respiratory motor control / G. S. Mitchell, S. M. Johnson // J. Appl. Physiol. - 2003. -Vol. 94. - P. 358-374.Chronic intermittent hypoxia enchances facilitation ventilatory long-term facilitation in awake rats / M. McGuire [et al.] // J. Appl. Physiol. - 2003. - Vol. 95. - P. 1499-1508.Chronic intermittent hypoxia enchances facilitation ventilatory long-term facilitation in awake rats / M. McGuire [et al.] // J. Appl. Physiol. - 2003. - Vol. 95. - P. 1499-1508.Mohamed, S. Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnea? / S. Mohamed, G. S. Mitchell // Exp. Physiol. - 2007. - Vol. 97. - P. 27-37.Mohamed, S. Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnea? / S. Mohamed, G. S. Mitchell // Exp. Physiol. - 2007. - Vol. 97. - P. 27-37.Serotonin receptor (1A)-modulated dephosphorilation of glycine receptor-3: new mechanism of breathing control for compensation of opioid-induced respiratory depression without loss of analgesia / T. Manzke [et al.] // Smerz. - 2011. -Vol. 25, N 3. - P. 272-281.Serotonin receptor (1A)-modulated dephosphorilation of glycine receptor-3: new mechanism of breathing control for compensation of opioid-induced respiratory depression without loss of analgesia / T. Manzke [et al.] // Smerz. - 2011. -Vol. 25, N 3. - P. 272-281.Shevtsova, N. A. Computational modeling of 5-HT receptor-mediated reorganization of the brainstem respiratory network / N. A. Shevtsova, T. Manzke, V. Molkov // Eur. J. Neurosci. - 2011. - Vol. 34, N 8. - P. 1276-1291.Shevtsova, N. A. Computational modeling of 5-HT receptor-mediated reorganization of the brainstem respiratory network / N. A. Shevtsova, T. Manzke, V. Molkov // Eur. J. Neurosci. - 2011. - Vol. 34, N 8. - P. 1276-1291.Kanamaru, M. Effect of dorsomedial medullary 5-HT2 receptor antagonism on initial ventilarory airway responses to hypercapnic hypoxia in mice / M. Kanamaru, T. Sugita, I. Homma // Exp. Brain Res. - 2013. - Vol. 230, N 4. - P. 547-554.Kanamaru, M. Effect of dorsomedial medullary 5-HT2 receptor antagonism on initial ventilarory airway responses to hypercapnic hypoxia in mice / M. Kanamaru, T. Sugita, I. Homma // Exp. Brain Res. - 2013. - Vol. 230, N 4. - P. 547-554.Volgin, D. V. Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons / D. V. Volgin, G. M. Stettner, L. Kubin // Respir. Physiol. Neurobiol. - 2013. - Vol. 188, N 3. - P. 301-307.Volgin, D. V. Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons / D. V. Volgin, G. M. Stettner, L. Kubin // Respir. Physiol. Neurobiol. - 2013. - Vol. 188, N 3. - P. 301-307.A systеmatic reviеw and meta-analysis of the assotiation between serotoninergic gene polymophisms and obstructive sleep apnea syndrome / H. Xu [et al.] // PLoS One. - 2014. - Vol. 9, N 1. - P. e86460.A systеmatic reviеw and meta-analysis of the assotiation between serotoninergic gene polymophisms and obstructive sleep apnea syndrome / H. Xu [et al.] // PLoS One. - 2014. - Vol. 9, N 1. - P. e86460.De Carvalho, T. B. Relationship of obstructive sleep apnea syndrome with the 5-HT(2A)-receptor gene in Brazilian patients / T. B. De Carvalho // Sleep Breath. - 2013. - Vol. 17, N 1. - P. 57-62.De Carvalho, T. B. Relationship of obstructive sleep apnea syndrome with the 5-HT(2A)-receptor gene in Brazilian patients / T. B. De Carvalho // Sleep Breath. - 2013. - Vol. 17, N 1. - P. 57-62.Piatto,V. B. Polimorphism in the 5-HTR(2A) gene related to obstructive sleep apnea syndrome / V. B. Piatto, T. B. N. S. Carvalho, I. de Marchi // Braz. J. Othorhinolaryngol. - 2011. - Vol. 77, N 3. - P. 348-355.Piatto,V. B. Polimorphism in the 5-HTR(2A) gene related to obstructive sleep apnea syndrome / V. B. Piatto, T. B. N. S. Carvalho, I. de Marchi // Braz. J. Othorhinolaryngol. - 2011. - Vol. 77, N 3. - P. 348-355.Association of the 5-HT2-receptor gene polymorphysms with obstructive sleep apnea hypopnea syndrome in Chinese Han population / G. Yin [et al.] // Acta Otolaryngol. - 2012. - Vol. 132, N 2. - P. 203-209.Association of the 5-HT2-receptor gene polymorphysms with obstructive sleep apnea hypopnea syndrome in Chinese Han population / G. Yin [et al.] // Acta Otolaryngol. - 2012. - Vol. 132, N 2. - P. 203-209.Association study of serotonin transporter gene polymorphisms with obstructive sleep apnea syndrome in Chinese Han population / W. Yue [et al.] // Sleep. - 2009. - Vol. 31, N 11. - P. 1535-1541.Association study of serotonin transporter gene polymorphisms with obstructive sleep apnea syndrome in Chinese Han population / W. Yue [et al.] // Sleep. - 2009. - Vol. 31, N 11. - P. 1535-1541.Ling, L. Serotonin and NMDA receptors in respiratory long-term facilitation / L. Ling // Respir. Physiol. Neurobiol. -2008. - Vol. 164, N 1-2. - P. 233-241.Ling, L. Serotonin and NMDA receptors in respiratory long-term facilitation / L. Ling // Respir. Physiol. Neurobiol. -2008. - Vol. 164, N 1-2. - P. 233-241.Say, M. Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent Hypercapnic hypoxia (IHH) and nicotine / M. Say, R. Machaalani, K. A. Waters // Brain Res. - 2007. - Vol. 1152. - P. 17-26.Say, M. Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent Hypercapnic hypoxia (IHH) and nicotine / M. Say, R. Machaalani, K. A. Waters // Brain Res. - 2007. - Vol. 1152. - P. 17-26.Bradford, A. Does episodic hypoxia affect upper airway dilatator muscle function? Implications for the pathophysiology of obstructive sleep apnoea // A. Bradford, M. McGuire, K. D. O'Halloran // Respir. Physiol. Neurobiol. - 2005. -Vol. 147. - P. 223-234.Bradford, A. Does episodic hypoxia affect upper airway dilatator muscle function? Implications for the pathophysiology of obstructive sleep apnoea // A. Bradford, M. McGuire, K. D. O'Halloran // Respir. Physiol. Neurobiol. - 2005. -Vol. 147. - P. 223-234.Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve aut / S. C. Veasey [et al.] // Am. J. Respir Crit. Care Med. - 2004. - Vol. 170. - P. 665-672.Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve aut / S. C. Veasey [et al.] // Am. J. Respir Crit. Care Med. - 2004. - Vol. 170. - P. 665-672.Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus / J. Rukhadze [et al.] // Am. J. Respir. Crit Care Med. - 2010. - Vol. 182, N 10. - P. 1321-1329.Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus / J. Rukhadze [et al.] // Am. J. Respir. Crit Care Med. - 2010. - Vol. 182, N 10. - P. 1321-1329.Kaur, S. Glutamatergic signaling from the Parabrachial nucleus plays a critical role in hypercapnic arousal / S. Kaur, N. P. Pedersen, S. Yokota // The J. of Neurosci. - 2013. - Vol. 33. - P. 7627-7640.Kaur, S. Glutamatergic signaling from the Parabrachial nucleus plays a critical role in hypercapnic arousal / S. Kaur, N. P. Pedersen, S. Yokota // The J. of Neurosci. - 2013. - Vol. 33. - P. 7627-7640.Short-term potentiation in the control of Pharingeal muscles in obstructive apnea patients / M. Younes, A. Loewen, M. Ostrowski, P. Hanly // Sleep. - 2014. - Vol. 37, N 11. - P. 1833-1849.Short-term potentiation in the control of Pharingeal muscles in obstructive apnea patients / M. Younes, A. Loewen, M. Ostrowski, P. Hanly // Sleep. - 2014. - Vol. 37, N 11. - P. 1833-1849.DeDios, J. A. New and unconventional treatments for obstructive sleep apnea. / J. A. De Dios, S. D. Brass // Neurothera-peutics. - 2012. - Vol. 9, N 4. - P. 702-709.DeDios, J. A. New and unconventional treatments for obstructive sleep apnea. / J. A. De Dios, S. D. Brass // Neurothera-peutics. - 2012. - Vol. 9, N 4. - P. 702-709.Lin, C. M. Pharmacotherapy of obstructive sleep apnea / C. M. Lin, Y. S. Huang, C. Guilleminault // Expert Opin. Pharmacother. - 2012. - Vol. 13, N 6. - P. 702-709.Lin, C. M. Pharmacotherapy of obstructive sleep apnea / C. M. Lin, Y. S. Huang, C. Guilleminault // Expert Opin. Pharmacother. - 2012. - Vol. 13, N 6. - P. 702-709.Chamberlin, N. L. Brain circuitry mediating arousal from obstructive sleep apnea / N. L. Chamberlin // Curr. Opin. Neurobiol. - 2013. - Vol. 23, N 5. - P. 774-779.Chamberlin, N. L. Brain circuitry mediating arousal from obstructive sleep apnea / N. L. Chamberlin // Curr. Opin. Neurobiol. - 2013. - Vol. 23, N 5. - P. 774-779.Соотношение центральных и периферических механизмов при развитии синдрома обструктивного апноэ сна / Ж. В. Колядич [и др.] // Отоларингология. Восточная Европа. - 2014. - № 4. - С. 13-20.Соотношение центральных и периферических механизмов при развитии синдрома обструктивного апноэ сна / Ж. В. Колядич [и др.] // Отоларингология. Восточная Европа. - 2014. - № 4. - С. 13-20.Анатомические особенности орофарингеальной области как предрасполагающий фактор синдрома обструк-тивного апноэ во сне / Ж. В. Колядич [и др.] // Отоларингология. Восточная Европа. - 2014. - Т. 17, № 4. - С. 8-12.Анатомические особенности орофарингеальной области как предрасполагающий фактор синдрома обструк-тивного апноэ во сне / Ж. В. Колядич [и др.] // Отоларингология. Восточная Европа. - 2014. - Т. 17, № 4. - С. 8-12.Brzecka, A. Role of hypercapnia in brain oxygenation in sleep-disordered breathing / A. Brzecka // Acta Neurol. Exp. -2007. - Vol. 67. - P. 192-206.Brzecka, A. Role of hypercapnia in brain oxygenation in sleep-disordered breathing / A. Brzecka // Acta Neurol. Exp. -2007. - Vol. 67. - P. 192-206.Xie, A. Effects of stabilizing or increasing respiratory motor outputs on obstructive apnea / A. Xie, M. Teodorescu, D. F. Pegelow // J. of Appl. Physiol. - 2013. - Vol. 115, N 1. - P. 22-33.Xie, A. Effects of stabilizing or increasing respiratory motor outputs on obstructive apnea / A. Xie, M. Teodorescu, D. F. Pegelow // J. of Appl. Physiol. - 2013. - Vol. 115, N 1. - P. 22-33.Response time and sensitivity of ventilatory response to CO2 in unanesthetized intact dogs: control is peripheral che-moreceptors / C. A. Smith [et al.] // J. Appl. Physiol. - 2006. - Vol. 100. - P. 13-19.Response time and sensitivity of ventilatory response to CO2 in unanesthetized intact dogs: control is peripheral che-moreceptors / C. A. Smith [et al.] // J. Appl. Physiol. - 2006. - Vol. 100. - P. 13-19.Marina, N. Essential role of Phox2b-expressing ventrolateral brainstem neurons in to chemosensory control of inspiration and expiration / N. Marina, A. P. Abdala, S. Trapp // The J. of Neurosci. - 2010. - Vol. 30. - P. 12466-12473.Marina, N. Essential role of Phox2b-expressing ventrolateral brainstem neurons in to chemosensory control of inspiration and expiration / N. Marina, A. P. Abdala, S. Trapp // The J. of Neurosci. - 2010. - Vol. 30. - P. 12466-12473.Optogenetic stimulation of C1 and RTN neurons confuses sleep state-dependent cardiorespiratory stimulation and arousal in rats / S. B. G. Abbott [et al.] // Hypertension. - 2013. - Vol. 61. - P. 835-841.Optogenetic stimulation of C1 and RTN neurons confuses sleep state-dependent cardiorespiratory stimulation and arousal in rats / S. B. G. Abbott [et al.] // Hypertension. - 2013. - Vol. 61. - P. 835-841.Rosin, D. L. Afferent and efferent connections of the rat retrotrapezoid nucleus / D. L. Rosin, D. A. Chang, P. Guyenet // J. Comp. Neurol. - 2006. - Vol. 499. - P. 64-89.Rosin, D. L. Afferent and efferent connections of the rat retrotrapezoid nucleus / D. L. Rosin, D. A. Chang, P. Guyenet // J. Comp. Neurol. - 2006. - Vol. 499. - P. 64-89.Smith, H. R. Activation of 5-HT2A-receptors recovers hypercania-induced arousal in genetically central 5-HT-neuron deficient mice / H. R. Smith, G. B. Richerson, G. E. Buchanan // Programm #799.07 / BBB8 Neuroscience Meeting Planner. Society for Neuroscience; New Orleans, LA., 2012.Smith, H. R. Activation of 5-HT2A-receptors recovers hypercania-induced arousal in genetically central 5-HT-neuron deficient mice / H. R. Smith, G. B. Richerson, G. E. Buchanan // Programm #799.07 / BBB8 Neuroscience Meeting Planner. Society for Neuroscience; New Orleans, LA., 2012.Toward, M. A. Increased brain serotonin corrects CO2 chemosensitivity in Mecp2-deficient mice / M. A. Toward, A. P. Ablata, S. J. Knopp // Exp Physiol. - 2013. - Vol. 98, N 3. - P. 842-849.Toward, M. A. Increased brain serotonin corrects CO2 chemosensitivity in Mecp2-deficient mice / M. A. Toward, A. P. Ablata, S. J. Knopp // Exp Physiol. - 2013. - Vol. 98, N 3. - P. 842-849.Influence of inhibitory serotoninergic inputs tj orexin hypocretin neurons on the diurnal rhytm of sleep and wakefulness / S. Tabuchi [et al.] // Sleep. - 2013. - Vol. 36, N 9. - P. 1391-1404.Influence of inhibitory serotoninergic inputs tj orexin hypocretin neurons on the diurnal rhytm of sleep and wakefulness / S. Tabuchi [et al.] // Sleep. - 2013. - Vol. 36, N 9. - P. 1391-1404.The sleep-wake cycle and motor activity, but not temperature are disrupted over the light-dark cycle in mice genetically depleted of serotonin / J. Z. Salarewicz [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2015. - Vol. 308, N 1. -P. 10-17.The sleep-wake cycle and motor activity, but not temperature are disrupted over the light-dark cycle in mice genetically depleted of serotonin / J. Z. Salarewicz [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2015. - Vol. 308, N 1. -P. 10-17.Effects of chronic sleep fragmentation on wake-active neurons and the hypercapnic arousal response / Y. Li [et al.] // Sleep. - 2014. - Vol. 37, N 1. - P. 51-64.Effects of chronic sleep fragmentation on wake-active neurons and the hypercapnic arousal response / Y. Li [et al.] // Sleep. - 2014. - Vol. 37, N 1. - P. 51-64.Central and peripheral factors contributing to obstructive sleep apneas / J. M. Ramirez [et al.] // Resp. Physiol. Neurobiol. - 2013. - Vol. 189, N 2. - P. 344-353.Central and peripheral factors contributing to obstructive sleep apneas / J. M. Ramirez [et al.] // Resp. Physiol. Neurobiol. - 2013. - Vol. 189, N 2. - P. 344-353.Melancom, M. O. Exercise and sleep in aging:emphasis on serotonin / M. O. Melancom, D. Lorran, I. J. Dionne // Pathol. Biol. (Paris). - 2014. - Vol. 62, N 5. - P. 276-283.Melancom, M. O. Exercise and sleep in aging:emphasis on serotonin / M. O. Melancom, D. Lorran, I. J. Dionne // Pathol. Biol. (Paris). - 2014. - Vol. 62, N 5. - P. 276-283.Stem, A. L. Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease / A. L. Stem, N. Naidoo // Springerplus. - 2015. - Vol. 4, N - doi 10.1186/s40064-014-0777-6. e. collection 2015.Stem, A. L. Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease / A. L. Stem, N. Naidoo // Springerplus. - 2015. - Vol. 4, N - doi 10.1186/s40064-014-0777-6. e. collection 2015.
The authors declare that there are no conflicts of interest present.