vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-216Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEФармакодинамические взаимодействия редокс-модулирующих аминокислот L-аргинина и таурина с плейотропными антиоксидантамиPharmacodynamic interactions of the redox modulating amino acids L-arginine and taurine with pleiotropic anti-oxidantsБизунокН. А.BizunokN. A.bizunokna@bsmu.byБелорусский государственный медицинский университетBelarusian State Medical University201506062016046884Copyright © Бизунок Н.А., 20162016Бизунок Н.А.Bizunok N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/216

М) в молярных соотношениях 1:1-1:100 (CI = 0 ,56-0,04). Компоненты этих комбинаций не только дополняют друг друга по абсолютному антирадикальному спектру и биологической активности, но и взаимно ускоряют радикальные взаимодействия и рассматриваются как основа для разработки новых лекарственных средств цитопротекторного и антиоксидантного действия. Включение в комбинацию дополнительного соединения может альтернативно изменить характер взаимодействия ее компонентов, что свидетельствует о необходимости всестороннего доклинического изучения любых сочетаний лекарственных средств.

М) in molar ratios of 1:1-1:100 (CI = 0.56-0.04). The components of such combinations are not only complementary another absolute anti-radical spectrum and biological activity, but also accelerate the radical interaction with each other and are considered as the basis for developing new cytoprotective and antioxidant drugs. It is also shown that the inclusion of an additional component in the synergistic combination can alter the character of the components interaction to antagonism and the resultant biological effect of the combination, which in turn indicates the urgent need for a comprehensive pre-clinical study of any drugs combinations.

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