vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestim-210Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEЗафранскаяМ. М.ZafranskayaM. M.zafranskaya@gmail.comНижегородоваД. Б.NizheharodavaD. B.nzh@tut.byКондратовичТ. В.LicandratovichT. V.kondratovich89@list.ruЮркевичМ. Ю.YurkevichM. J.marija4567@gmail.comКомиссаровК. С.KomissarovK. S.kirill_ka@tut.byИванчикГ. И.IvanchikH. I.immunology.by@gmail.comКулиничС. С.KulinichS. S.bagatka_sv@mail.ruПилотовичВ. С.PilotovichV. S.pilotovich@mail.ruБелорусская медицинская академия последипломного образованияBelarusian Medical Academy of Postgraduate Education201506062016043037Copyright © Зафранская М.М., Нижегородова Д.Б., Кондратович Т.В., Юркевич М.Ю., Комиссаров К.С., Иванчик Г.И., Кулинич С.С., Пилотович В.С., 20162016Зафранская М.М., Нижегородова Д.Б., Кондратович Т.В., Юркевич М.Ю., Комиссаров К.С., Иванчик Г.И., Кулинич С.С., Пилотович В.С.Zafranskaya M.M., Nizheharodava D.B., Licandratovich T.V., Yurkevich M.J., Komissarov K.S., Ivanchik H.I., Kulinich S.S., Pilotovich V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/210

Изучен иммуномодулирующий эффект свежевыделенных некультивируемых мононуклеаров костного мозга (МоКМ) у крыс. Установлено, что МоКМ оказывают выраженное in vitro и in vivo антипролиферативное действие на митоген-стимулированные спленоциты крыс, сопоставимое с иммуносупрессивным действием мезенхимальных стволовых клеток. Это открывает перспективу применения МоКМ в терапии острых состояний с воспалительным компонентом, включая острую ишемическую нефропатию, для предотвращения отдаленных последствий ишемиче-ского поражения органов.

The immunomodulatory properties of fresh isolated uncultivated bone marrow mononuclear cells (BMMNC) were estimated. Revealed BMMNC expressed in vitro and in vivo antiproliferative effects on mitogen-stimulated rat splenocytes comparable with the mesenchymal stem cells immunosuppression, which offers the challenge of the BMMNC application in therapy of acute conditions with an inflammatory component including acute ischemic nephropathy for preventing ischemic organs affection long-term effects.

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The authors declare that there are no conflicts of interest present.