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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestim</journal-id><journal-title-group><journal-title xml:lang="ru">Известия Национальной  академии наук Беларуси. Серия медицинских наук</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of the National Academy of Sciences of Belarus, Medical series</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-6023</issn><issn pub-type="epub">2524-2350</issn><publisher><publisher-name>The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vestim-200</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL AND EXPERIMENTAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Состояние перекисного окислениябелков плазмы крови крыс при сахарном диабете и артериальной гипертензии</article-title><trans-title-group xml:lang="en"><trans-title>Peroxidation state of plasma proteins inrats with diabetes mellitus and arterial hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калиновская</surname><given-names>Е. И.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондрашова</surname><given-names>С. Б.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Благун</surname><given-names>Е. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павловец</surname><given-names>Л. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Институт физиологии НАН Беларуси</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2016</year></pub-date><volume>0</volume><issue>4</issue><fpage>78</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Калиновская Е.И., Кондрашова С.Б., Благун Е.В., Павловец Л.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Калиновская Е.И., Кондрашова С.Б., Благун Е.В., Павловец Л.В.</copyright-holder><copyright-holder xml:lang="en">Калиновская Е.И., Кондрашова С.Б., Благун Е.В., Павловец Л.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestimed.belnauka.by/jour/article/view/200">https://vestimed.belnauka.by/jour/article/view/200</self-uri><abstract><p>Изучено состояние перекисного окисления белков плазмы крови крыс при сахарном диабете (СД) и артериальной гипертензии (АГ). Установлено, что процесс перекисного окисления белков в крови экспериментальных животных при изучаемых патологических состояниях разнонаправленный: он усиливается при СД и ослабляется при АГ. Таким образом, характер перекисного окисления белков может быть одним из ранних индикаторов повреждения ткани, что обосновывает дальнейшее изучение роли свободнорадикальной модификации белков в биохимических механизмах становления и прогрессирования различных патологических состояний, в частности АГ и СД, а также использование данного механизма в диагностике различных состояний организма.</p></abstract><trans-abstract xml:lang="en"><p>The peroxidation state of plasma proteins in rats with diabetes mellitus and arterial hypertension was studied. Data showed that the process of peroxidation of plasma proteins in experimental animals is multidirectional in the studied pathological state. It increases at diabetes mellitus and goes down at arterial hypertension. Thus, the nature of peroxidation of plasma proteins can be one of the early indicators of tissue damage, which justifies a further investigation of the role of free radical modification of proteins in the biochemical mechanisms of the formation and progression of various pathological states such as diabetes mellitus and arterial hypertension, as well as the use of this mechanism in the diagnosis of different organism states.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аметов А. С., Дедов И. И. // Рус. мед. журн. 2005. Т.13, № 6. С. 230, 288-294.</mixed-citation><mixed-citation xml:lang="en">Аметов А. С., Дедов И. И. // Рус. мед. журн. 2005. Т.13, № 6. С. 230, 288-294.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Боев К. В., Василенко Д. В., Маслов А. 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