vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2026-23-3-223-228vestim-1104Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEНарушение окислительно-восстановительного статуса эритроцитов и изменение гемоглобина в зависимости от тяжести заболевания при хронической обструктивной болезни лёгкихImpairment of erythrocyte redox status and hemoglobin alterations across disease severity in chronic obstructive pulmonary diseasehttps://orcid.org/0000-0003-3763-0455МуминовД. K.MuminovD. K.

Муминов Даврон Кадирович – д-р мед. наук, профессор, профессор кафедры внутренних болезней, нефрологии и гемодиализа

ул. Богишамол, 223, 100140, Юнусабадский р-н, г. Ташкент

Davron K. Muminov – D. Sc. (Med.), Professor, Professor of the Department of Internal Medicine, nephrology and hemodialysis

223, Bog‘ishamol Str., 100140, Yunusabad District, Tashkent

dr.muminov1@gmail.comhttps://orcid.org/0000-0003-2344-3544ДаминоваЛ. T.DaminovaL. T.

Даминова Лола Тургунпулатовна – д-р мед. наук, профессор, профессор кафедры семейной медицины и клинической фармакологии

ул. Богишамол, 223, 100140, Юнусабадский р-н, г. Ташкент

Lola T. Daminova – D. Sc. (Med.), Professor, Professor of the Department of Family Medicine and Clinical Pharmacology

223, Bog‘ishamol Str., 100140, Yunusabad District, Tashkent

dr.daminova@gmail.comhttps://orcid.org/0000-0001-7645-3952KлимковичН. Н.KlimkovichN. N.

Климкович Наталья Николаевна – д-р мед. наук, доцент, заведующий кафедрой детской онкологии, гематологии и иммунологии

пр. Дзержинского, 83, 220083, г. Минск

Natalia N. Klimkovich – D. Sc. (Med.), Associate Professor, Head of the Department of Pediatric Oncology, Hematology and Immunology

83, Dzerzhinsky Ave., 220083, Minsk

natalliaklimkovich@mail.ruhttps://orcid.org/0000-0003-0119-9288МуминоваС. У.MuminovaS. U.

Муминова Ситорахон Улугбековна – канд. мед. наук, доцент, доцент кафедры эндокринологии

ул. Богишамол, 223, 100140, Юнусабадский р-н, г. Ташкент

Sitorakhon U. Muminova – Ph. D. (Med.), Associate Professor, Associate Professor of the Department of Endocrinology

223, Bog‘ishamol Str., 100140, Yunusabad District, Tashkent

dr.muminova@gmail.comТашкентский государственный медицинский университетУзбекистанTashkent State Medical UniversityUzbekistanБелорусский государственный медицинский университетБеларусьBelarusian State Medical UniversityBelarus202630082026233223228Copyright © Муминов Д.K., Даминова Л.T., Kлимкович Н.Н., Муминова С.У., 20262026Муминов Д.K., Даминова Л.T., Kлимкович Н.Н., Муминова С.У.Muminov D.K., Daminova L.T., Klimkovich N.N., Muminova S.U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/1104

Системная гипоксия при хронической обструктивной болезни лёгких (ХОБЛ) традиционно связывается с нарушением лёгочного газообмена, однако изменения в регуляции окислительно-восстановительного статуса эритроцитов могут дополнительно ухудшать транспорт кислорода. Целью исследования явилась оценка функции электронного и кислородного транспорта эритроцитов на разных стадиях ХОБЛ.В одноцентровое поперечное исследование включены 150 клинически стабильных пациентов с ХОБЛ (легкая форма – n = 54, умеренная форма – n = 59, тяжелая форма – n = 37) и 40 здоровых контрольных лиц. Определены содержание цитохрома С и цитохрома b₅ в эритроцитах, активность НАДН- и НАДФН-редуктаз, активность глюкозо- 6-фосфатдегидрогеназы, уровни 2,3-дифосфоглицерата, фракции гемоглобина и параметры газового состава крови. У пациентов с ХОБЛ наблюдалось снижение содержания цитохрома С и цитохрома b₅ в эритроцитах, а также снижение активности глюкозо-6-фосфатдегидрогеназы, сопровождающееся повышением активности редуктазы (все – p < 0,001). Установлено снижение уровня оксигемоглобина, в то время как содержание дезоксигемоглобина и метгемоглобина повышалось с усугублением тяжести заболевания. Повышенный уровень 2,3-дифосфоглицерата может свидетельствовать о частичной компенсации состояния. Анализ газов крови позволил выявить прогрессирующую гипоксию и метаболические нарушения. Прогрессирующее нарушение окислительно-восстановительного статуса эритроцитов и изменения гемоглобина могут усугублять лёгочную дисфункцию за счет нарушения системной доставки кислорода при ХОБЛ.

Systemic hypoxemia in chronic obstructive pulmonary disease (COPD) is traditionally attributed to impaired pulmonary gas exchange. However, alterations in erythrocyte redox regulation may further compromise oxygen transport.The objective of this study is to evaluate the erythrocyte electron-transport and oxygen-transport functions at different stages of COPD.This single-center cross-sectional study included 150 clinically stable COPD patients (mild – n = 54, moderate – n = 59, severe – n = 37) and 40 healthy controls. Erythrocyte cytochrome C and cytochrome b₅ content, NADH- and NADPH-dependent reductase activities, glucose-6-phosphate dehydrogenase activity, 2,3-diphosphoglycerate levels, hemoglobin fractions, and blood gas parameters were measured. COPD patients demonstrated reduced erythrocyte cytochrome C and cytochrome b₅ content and decreased glucose-6-phosphate dehydrogenase activity, accompanied by increased reductase activities (all – p < 0.001). Oxyhemoglobin levels declined, while deoxyhemoglobin and methemoglobin levels increased with disease severity. Elevated 2,3-diphosphoglycerate levels suggested partial compensation. Blood gas analysis revealed progressive hypoxemia and metabolic disturbance. It has been posited that progressive impairment of erythrocyte redox status and hemoglobin alterations may contribute to impaired systemic oxygen delivery in COPD beyond pulmonary dysfunction.

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The authors declare that there are no conflicts of interest present.