vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2026-23-2-147-156vestim-1087Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEСостояние тканей периодонта у пациентов с воспалительной патологией кишечникаCondition of periodontal tissues in patients with inflammatory intestinal pathologyhttps://orcid.org/0000-0002-7450-3757РубниковичС. П.RubnikovichS. P.

Рубникович Сергей Петрович – член-корреспондент, д-р мед. наук, профессор, ректор 

пр. Дзержинского, 83, 220083, г. Минск

Sergey P. Rubnikovich – Corresponding Member, Sc. (Med.), Professor, Rector

83, Dzerzhinsky Ave., 220083, Minsk

rubnikovichs@mail.ruhttps://orcid.org/0000-0002-1686-1820БекжановаО. Е.BekjanovaO. E.

Бекжанова Ольга Есеновна – д-р мед. наук, профессор, заведующий кафедрой

ул. Фараби, 2, 100109, г. Ташкент

Olga Е. Bekjanova – D. Sc. (Med.), Professor, Head of the Department

2. Farabi Str., 100109, Tashkent

bekjanovaolga@mail.ruhttps://orcid.org/0009-0004-7317-130XОлимжоновК. Ж.OlimjonovK. J.

Олимжонов Камрон Жасурович – ассистент кафедры 

ул. Фараби, 2, 100109, г. Ташкент

Kamron J. Olimjonov – Assistant Professor of the Department 

2. Farabi Str., 100109, Tashkent

Kamronbek440@gmail.comАлимоваД. М.AlimovaD. M.

Алимова Доно Миржамаловна – д-р мед. наук, доцент 

ул. Фараби, 2, 100109, г. Ташкент

Dono M. Alimova – D. Sc. (Med.), Associate Professor 

2. Farabi Str., 100109, Tashkent

stom_81@bk.ruhttps://orcid.org/0009-0009-8516-172XАлимоваС. Х.AlimovaS. X.

Алимова Севара Хаитматовна – канд. мед. наук, доцент 

ул. Фараби, 2, 100109, г. Ташкент

Sevara X. Alimova – Ph. D. (Med.), Associate Professor 

2. Farabi Str., 100109, Tashkent

alimovasevara217@gmail.comhttps://orcid.org/0009-0000-9979-4821АстанакуловаМ. М.AstanakulovaM. M.

Астанакулова Муниса Мирзаевна – канд. мед. наук, доцент 

ул. Фараби, 2, 100109, г. Ташкент

Munisa M. Astanakulova – Ph. D. (Med.), Associate Professor 

2. Farabi Str., 100109, Tashkent

munisa.suyunova@mail.ruhttps://orcid.org/0000-0003-0917-7972ДенисоваЮ. Л.DenisovaYu. L

Денисова Юлия Леонидовна – д-р мед. наук, профессор 

пр. Дзержинского, 83, 220083, г. Минск

Yuliya L. Denisova – D. Sc. (Med.), Professor

83, Dzerzhinski Ave., 220083, Minsk

denisova-yul@mail.ruhttps://orcid.org/0009-0009-1509-1906АхмаджоновТ. Л.AhmadjanovT. L.

Ахмаджанов Темурбек Лазизжон – ассистент кафедры 

ул. Фараби, 2, 100109, г. Ташкент

Temurbek L. Ahmadjanov – Assistant Professor of the Department 

2. Farabi Str., 100109, Tashkent

takhmadjonov@mail.ruБелорусский государственный медицинский университетБеларусьBelarusian State Medical UniversityBelarusТашкентский государственный медицинский университетУзбекистанTashkent State Medical UniversityUzbekistan202627052026232147156Copyright © Рубникович С.П., Бекжанова О.Е., Олимжонов К.Ж., Алимова Д.М., Алимова С.Х., Астанакулова М.М., Денисова Ю.Л., Ахмаджонов Т.Л., 20262026Рубникович С.П., Бекжанова О.Е., Олимжонов К.Ж., Алимова Д.М., Алимова С.Х., Астанакулова М.М., Денисова Ю.Л., Ахмаджонов Т.Л.Rubnikovich S.P., Bekjanova O.E., Olimjonov K.J., Alimova D.M., Alimova S.X., Astanakulova M.M., Denisova Y.L., Ahmadjanov T.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/1087

Целый ряд доказательств взаимоотягощающего влияния патологии периодонта и кишечника через многочисленные микробиологические, иммунологические, психологические и метаболические ассоциации определяет повышенный интерес к проблеме патологии периодонта у пациентов с воспалительными заболеваниями кишечника (ВЗК).

Этиопатогенез ВЗК, т. е. язвенного колита и болезни Крона, во многом сходен с периодонтитом. Оба заболевания связаны с чрезмерной воспалительной реакцией слизистой оболочки кишечника или полости рта на микробный триггер у восприимчивого хозяина.

Цель исследования – оценить тяжесть клинического течения патологии периодонта у пациентов с ВЗК.

ВЗК и периодонтит являются патологией воспалительного генеза, хронического, прогрессирующего течения, они объединены общностью патогенеза, заключающегося во взаимодействии и взаимоусугублении нарушений микробиоценоза и иммуновоспалительных реакций. ВЗК – один из важнейших факторов риска развития и тяжелого течения периодонтита. Нами установлено, что у пациентов с ВЗК риск тяжелого пародонтита ΙΙΙ–ΙV степени составляет 2,431 (95 % ДИ 1,704–3,470), а этиологическая доля вклада ВЗК в риск периодонтита ΙΙΙ–ΙV степени равна 58,86 %. Наличие фактора риска увеличивает тяжесть патологии периодонта.

Достоверно более высокая распространенность периодонтита была обнаружена у пациентов с ВЗК по сравнению с группой сравнения – 94,16 % против 83,97 % ( p < 0,001).

Numerous evidence of the mutually aggravating influence of periodontal and intestinal pathologies through numerous microbiological, immunological, psychological, and metabolic associations determines the increased interest in the problem of periodontal pathology in patients with inflammatory bowel diseases.

The etiopathogenesis of inflammatory bowel diseases, i. e., ulcerative colitis and Crohn’s disease, is largely similar to periodontitis. Both diseases are associated with an excessive inflammatory reaction of the intestinal mucosa or oral cavity to microbial triggers in the susceptible host.

The purpose of the research is to assess the severity of the clinical course of periodontal pathology in patients with inflammatory bowel diseases.

Intestinal inflammatory diseases and periodontitis are pathologies of inflammatory genesis, chronic progressive course, united by a common pathogenesis consisting in the interaction and mutual aggravation of microbiocenosis disorders and immuno-inflammatory reaction. Inflammatory bowel diseases is one of the most important risk factors for the development and severity of periodontitis. We determined that in patients with inflammatory bowel diseases , the risk of severe periodontitis of the ΙΙΙ/ΙV degree is 2.431 (95 % CI 1.704–3.470), and the etiological contribution of inflammatory bowel diseases to the risk of periodontitis of the ΙΙΙ–ΙV degree is 58.86 %. The presence of a risk factor increases the severity of periodontal pathology.

A significantly higher prevalence of periodontitis was found in patients with inflammatory bowel diseases compared to the comparison group (94.16 % versus 83.97 % (p < 0.001). The presence of inflammatory bowel diseases significantly affects the risk of severe periodontal disease.

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The authors declare that there are no conflicts of interest present.