vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2026-23-1-7-18vestim-1069Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEСравнительная оценка регенерации кости при периимплантите с использованием остеопластических материалов на основе β-трикальцийфосфата и костного коллагенаComparative evaluation of bone regeneration in peri-implantitis using osteoplastic materials based on β-tricalcium phosphate and bone collagenhttps://orcid.org/0000-0002-7450-3757РубниковичС. П.RubnikovichS. P.

Рубникович Сергей Петрович – член-корреспондент, д-р мед. наук, профессор, ректор

пр. Дзержинского, 83, 220083, г. Минск

Sergey P. Rubnikovich – Corresponding Member, D. Sc. (Med.), Professor, Rector

83, Dzerzhinsky Ave., 220083, Minsk

rubnikovichs@mail.ruhttps://orcid.org/0009-0001-1663-3377ЮрасовА. Ю.YurasovA. Yu.

Юрасов Андрей Юрьевич – ассистент кафедры

ул. Ленина, 3, 450008, г. Уфа, Республика Башкортостан

Andrey Yu. Yurasov – Assistant of the Department

3, Lenin Str., 450008, Ufa, Republic of Bashkortostan

andreyyr@mail.ruhttps://orcid.org/0000-0003-1827-1629АверьяновС. B.AveryanovS. V.

Аверьянов Сергей Витальевич – д-р мед. наук, проф., заведующий кафедрой

ул. Ленина, 3, 450008, г. Уфа, Республика Башкортостан

Sergey V. Averyanov – D. Sc. (Med.), Professor, Head of the Department

3, Lenin Str., 450008, Ufa, Republic of Bashkortostan

sergei_aver@mail.ruhttps://orcid.org/0000-0002-4924-5792СиракС. В.SirakS. V.

Сирак Сергей Владимирович – д-р мед. наук, профессор, заведующий кафедрой

ул. Мира, 310, 355017, г. Ставрополь

Sergey V. Sirak – D. Sc. (Med.), Professor, Head of the Department

310, Mira Str., 355017, Stavropol

sergejsirak@yandex.ruhttps://orcid.org/0000-0003-0139-5094ГатилоН. А.GatiloI. A.

Гатило Ирина Анатольевна – канд. мед. наук, доцент

ул. Мира, 310, 355017, г. Ставрополь

Irina A. Gatilo – Ph. D. (Med.), Associate Professor 

310, Mira Str., 355017, Stavropol

chijgay@yandex.ruhttps://orcid.org/0000-0001-7004-3581ПериковаМ. Г.PerikovaM. G.

Перикова Мария Григорьевна – канд. мед. наук, доцент 

ул. Мира, 310, 355017, г. Ставрополь

Maria G. Perikovа – Ph. D. (Med.), Associate Professor 

310, Mira Str., 355017, Stavropol

https://orcid.org/0009-0000-5738-5501ЛеневВ. Н.LenevV. N.

Ленев Вадим Николаевич – канд. мед. наук, доцент 

ул. Мира, 310, 355017, г. Ставрополь

Vadim N. Lenev – Ph. D. (Med.), Associate Professor 

310, Mira Str., 355017, Stavropol

lenevstom@yandex.ruБелорусский государственный медицинский университетBelarusian State Medical UniversityБашкирский государственный медицинский университетBashkir State Medical UniversityСтавропольский государственный медицинский университетStavropol State Medical University202603032026231718Copyright © Рубникович С.П., Юрасов А.Ю., Аверьянов С.B., Сирак С.В., Гатило Н.А., Перикова М.Г., Ленев В.Н., 20262026Рубникович С.П., Юрасов А.Ю., Аверьянов С.B., Сирак С.В., Гатило Н.А., Перикова М.Г., Ленев В.Н.Rubnikovich S.P., Yurasov A.Y., Averyanov S.V., Sirak S.V., Gatilo I.A., Perikova M.G., Lenev V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/1069

Настоящее исследование посвящено оценке регенераторного потенциала костной ткани в зоне периимплантного дефекта при использовании костезамещающих материалов на основе β-трикальцийфосфата и костного коллагена.

Цель исследования – определить наличие, локализацию и активность остеогенных клеток в зоне периимплантного дефекта для оценки влияния костезамещающего материала на мобилизацию и пролиферацию клеток, ответственных за регенерацию кости.

В рамках эксперимента на овцах смоделирован периимплантит с созданием дефекта вокруг дентального имплантата (ДИ) с последующим его заполнением костезамещающими материалами на основе β-трикальцийфосфата (1-я основная группа) и костного коллагена (2-я основная группа). В контрольной группе периимплантатный дефект вели под кровяным сгустком. По истечении 2 месяцев проведены гистологические и иммуногистохимические исследования, выявлены активная пролиферация и дифференцировка плюрипотентных клеток, выраженная экспрессия маркеров CD34+, NSE+, EMA+ и Ki-67+.

Результаты показывают, что оба костезамещающих материала являются остеоиндуктивными, биосовместимыми и способствуют активации клеточных источников для регенерации костной ткани, а также оказывают положительное влияние на процессы неоангиогенеза и формирование ретикулофиброзной костной ткани. Эти данные подтверждают потенциал использования β-трикальцийфосфата и костного коллагена в клинической практике для восстановления костных дефектов при периимплантитах.

This study is devoted to the assessment of the regenerative potential of bone tissue in the peri-implant defect zone using bone substitutes based on β-tricalcium phosphate and bone collagen. The aim of the study is to determine the presence, localization and activity of pluripotent cells in the peri-implant defect zone to assess the effect of bone substitutes on the mobilization and proliferation of cells responsible for bone regeneration. As part of the experiment on sheep, peri-implantitis was modeled with the creation of a defect around the dental implant (DI) with its subsequent filling with bone substitutes based on β-tricalcium phosphate (the first main group) and bone collagen (the second main group). In the control group, the peri-implant defect was maintained under a blood clot. After two months, histological and immunohistochemical studies were performed, active proliferation and differentiation of pluripotent cells, pronounced expression of CD34+, NSE+, EMA+ and Ki-67+ markers were revealed. The results show that both bone-substituting materials are osteoinductive, biocompatible and promote the activation of cellular sources for bone tissue regeneration, and also have a positive effect on neoangiogenesis processes and the formation of reticulofibrous bone tissue. These data confirm the potential of using β-tricalcium phosphate and bone collagen in clinical practice for the restoration of bone defects in peri-implantitis.

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The authors declare that there are no conflicts of interest present.