vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2025-22-4-271-280vestim-1053Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEКардиопротекторный эффект дистантного ишемического кондиционирования при ишемии различной длительности в экспериментеCardioprotective effect of remote ischemic conditioning during ischemia of different duration in an experimentСеврукевичВ. В.SevrukevitchV. V.

Севрукевич Валерий Васильевич ‒ аспирант

пр-т Дзержинского, 83, 220116, г. Минск

Valery V. Sevrukevitch ‒ Postgraduate student

83, Dzerzhinski Ave., 220116, Minsk

valersev@gmail.comВисмонтФ. И.VismontF. I.

Висмонт Франтишек Иванович – член-корреспондент, д-р мед. наук, профессор, заведующий кафедрой

пр-т Дзержинского, 83, 220116, г. Минск

Frantishek I. Vismont – Corresponding Member

83, Dzerzhinski Ave., 220116, Minsk

patfiz@bsmu.byМрочекА. Г.MrochekA. G.

Мрочек Александр Геннадьевич ‒ академик, д-р мед. наук, профессор

пр-т Дзержинского, 83, 220116, г. Минск

Alexander G. Mrochek ‒ Academician, D. Sc. (Med.), Professor

83, Dzerzhinski Ave., 220116, Minsk

Белорусский государственный медицинский университетBelarusian State Medical University202504122025224271280Copyright © Севрукевич В.В., Висмонт Ф.И., Мрочек А.Г., 20252025Севрукевич В.В., Висмонт Ф.И., Мрочек А.Г.Sevrukevitch V.V., Vismont F.I., Mrochek A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/1053

Изучена кардиопротекторная эффективность дистантного ишемического перкондиционирования  (ДИПерК), дистантного ишемического посткондиционирования (ДИПостК 10′), а также их комбинаций в условиях ишемии миокарда различной продолжительности. Ишемия/реперфузия миокарда воспроизводилась путем 30-минутной окклюзии левой коронарной артерии с последующим периодом 120-минутной реперфузии либо путем 45-минутной окклюзии левой коронарной артерии с последующим периодом 120-минутной реперфузии. Все приведенные в настоящем исследовании алгоритмы дистантного ишемического кондиционирования в условиях ишемии длительностью 30 и 45 мин с последующей 120-минутной реперфузией вызывали выраженный кардиопротекторный эффект. Продемонстрировано, что комбинированное применение ДИПерК с ДИПостК 10′ в условиях ишемии длительностью 30 и 45 мин с последующей 120-минутной реперфузией оказывает сопоставимый кардиопротекторный эффект в сравнении с применением каждого из этих алгоритмов в отдельности. Ишемия длительностью 30 мин является более предпочтительной для разработки новых эффективных способов кардиопротекции.

The cardioprotective efficacy of remote ischemic preconditioning (RIPerC), remote ischemic postconditioning (RIPostC 10′), as well as their combinations, was studied under conditions of myocardial ischemia of varying durations. Myocardial ischemia/reperfusion was induced by 30-minute occlusion of the left coronary artery, followed by a 120-minute reperfusion period, or by a 45-minute occlusion of the left coronary artery, followed by a 120-minute reperfusion period. All remote ischemic conditioning protocols presented in this study demonstrated a pronounced cardioprotective effect under conditions of both 30-minute and 45-minute ischemia followed by 120 minutes of reperfusion. It was shown that the combined application of RIPerC and RIPostC 10′ under conditions of 30- and 45-minute ischemia followed by 120-minute reperfusion provides a cardioprotective effect comparable to that of each algorithm applied separately. Thirty-minute ischemia appears  to be more preferable for the development of new effective cardioprotective strategies.

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The authors declare that there are no conflicts of interest present.