vestimИзвестия Национальной академии наук Беларуси. Серия медицинских наукProceedings of the National Academy of Sciences of Belarus, Medical series1814-60232524-2350The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1814-6023-2025-22-1-65-72vestim-1016Research ArticleКЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНАCLINICAL AND EXPERIMENTAL MEDICINEПолиморфизм генов ММP-2, ММP-9, TIMP-2 и характер экспрессии матриксных металлопротеиназ типов 2 и 9 плаценты женщин с привычным невынашиванием беременностиPolymorphism of the MMP-2, MMP-9, TIMP-2 genes and the expression pattern of matrix metalloproteinases types 2 and 9 of the placenta of women with recurrent miscarriagehttps://orcid.org/0009-0005-6161-6946ГриневичТ. Н.GrinevichT. N.

Гриневич Татьяна Николаевна – канд. мед. наук, доцент

ул. Горького, 80, 230015, г. Гродно

Tatyana N. Grinevich – Ph. D. (Med.), Associate Professor

80, Gorky Str., 230015, Grodno

tgrinevich@yandex.byЛяликовС. А.LyalikovS. A.

Ляликов Сергей Александрович – д-р мед. наук, профессор, заведующий кафедрой

ул. Горького, 80, 230015, г. Гродно

Sergey A. Lyalikov – D. Sc. (Med.), Professor, Head  of the Department

80, Gorky Str., 230015, Grodno

lalikov@tut.byШульгаА. В.ShulgaA. V.

Шульга Андрей Васильевич – канд. мед. наук, доцент

ул. Горького, 80, 230015, г. Гродно

Andrey V. Shulga – Ph. D. (Med.), Associate Professor

80, Gorky Str., 230015, Grodno

grodnopat@gmail.comhttps://orcid.org/0009-0007-9576-2233КотМ. О.KotM. O.

Кот Максим Олегович – студент

ул. Горького, 80, 230015, г. Гродно

Maksim O. Kot – Student

80, Gorky Str., 230015, Grodno

Гродненский государственный медицинский университетGrodno State Medical University2025280220252216572Copyright © Гриневич Т.Н., Ляликов С.А., Шульга А.В., Кот М.О., 20252025Гриневич Т.Н., Ляликов С.А., Шульга А.В., Кот М.О.Grinevich T.N., Lyalikov S.A., Shulga A.V., Kot M.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestimed.belnauka.by/jour/article/view/1016

Изучены показатели экспрессии матриксных металлопротеиназ (ММР) типов 2 и 9 и полиморфизм генов ММР-2, ММР-9 и их тканевого ингибитора (TIMP-2) в плацентарной ткани женщин с ранними репродуктивными потерями. Установлено, что у женщин с привычным невынашиванием беременности в первом триместре экспрессия ММР-2 в препаратах плацентарной ткани существенно выше, чем у женщин с нормально протекающей беременностью. Выявлены ассоциации мутантного аллеля Т полиморфизма 735 C/T гена MMP-2 и мутантного аллеля С полиморфизма 418 G/C гена TIMP-2 с высоким уровнем экспрессии MMP-2. Уровни экспрессии MMP-9 в плаценте женщин с привычным выкидышем и с физиологическим течением беременности статистически значимо не различались.

Expression indices of matrix metalloproteinases (MMPs) of types 2 and 9 and polymorphism of MMP-2, MMP-9 and their tissue inhibitor (TIMP-2) genes in placental tissue of women with early reproductive losses were determined. MMP-2 expression in placental tissue preparations was found to be significantly higher among women with recurrent miscarriage in the first trimester pregnancy than in women with normal pregnancy. Associations of the mutant T allele of the 735 C/T polymorphism of the MMP-2 gene and the mutant C allele of the 418 G/C polymorphism of the TIMP-2 gene with  a high level of matrix MMP-2 expression were found. The level of MMP-9 expression in the placenta of women with recurrent miscarriage and with physiological pregnancy was not statistically significantly different.

матриксные металлопротеиназыпривычное невынашивание беременностиэкспрессияполиморфизмплацентаmatrix metalloproteinasesrecurrent miscarriageexpressionpolymorphismplacentaРабота выполнена при финансовой поддержке внутриуниверситетского научного гранта для аспирантов, докторантов и профессорско-преподавательского состава Гродненского государственного медицинского университета «Анализ ассоциаций аллельных вариантов генов системы матриксных металлопротеиназ девятого типа с ранними эмбриональными потерями у женщин с привычным невынашиванием беременности» (2022).The work was financially suppor- ted by the intra-university research grant for postgraduate students, doctoral students and academic staff of Grodno State Medical University “Analysis of associations of allelic variants of genes of the matrix metalloproteinase system type nine with early embryonic loss in women with habitual miscarriage of pregnancy” (2022).ReferencesDifferential activity of the gelatinases (matrix metalloproteinases 2 and 9) in the fetal membranes and decidua, associated with labour / S. 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The authors declare that there are no conflicts of interest present.